O6-METHYLGUANINE-DNA METHYLTRANSFERASE IS DOWNREGULATED IN TRANSFORMED ASTROCYTE CELLS: IMPLICATIONS FOR ANTI-GLIOMA THERAPIES

O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies

Abstract Background A novel alkylating agent, temozolomide, has Nursing Pillows proven efficacious in the treatment of malignant gliomas.However, expression of O6-methylguanine-DNA methyltransferase (MGMT) renders glioma cells resistant to the treatment, indicating that identification of mechanisms underlying the gene regulation of MGMT is highly r

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A singular PpaA/AerR-like protein in Rhodospirillum rubrum rules beyond the boundaries of photosynthesis in response to the intracellular redox state

ABSTRACT Photosynthesis (PS) in purple non-Sulfur bacteria (PNSB) is strictly controlled to avoid energy consumption and to prevent oxidative stress when oxygen is present.PpsR, a transcriptional repressor encoded in the photosynthesis gene cluster (PGC), is one of the main players in the regulation of PS-related genes.In some cases, PpsR does not

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Pyrenophora teres and Rhynchosporium secalis Establishment in a Mediterranean Malt Barley Field: Assessing Spatial, Temporal and Management Effects

Malt barley is one of the promising crops in Greece, mainly due to high yields and contract farming, which have led to an increase in malt barley acreage.Net form net blotch (NFNB), caused by Pyrenophora teres f.teres, and barley leaf scald, caused by Rhynchosporium secalis, are among the most important barley diseases worldwide and particularly in

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